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Cleavage of the sarcin–ricin loop of 23S rRNA differentially affects EF-G and EF-Tu binding
Ribotoxins are potent inhibitors of protein biosynthesis and inactivate ribosomes from a variety of organisms. The ribotoxin α-sarcin cleaves the large 23S ribosomal RNA (rRNA) at the universally conserved sarcin–ricin loop (SRL) leading to complete inactivation of the ribosome and cellular death. T...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896532/ https://ncbi.nlm.nih.gov/pubmed/20215430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq151 |
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