Cleavage of the sarcin–ricin loop of 23S rRNA differentially affects EF-G and EF-Tu binding

Ribotoxins are potent inhibitors of protein biosynthesis and inactivate ribosomes from a variety of organisms. The ribotoxin α-sarcin cleaves the large 23S ribosomal RNA (rRNA) at the universally conserved sarcin–ricin loop (SRL) leading to complete inactivation of the ribosome and cellular death. T...

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Détails bibliographiques
Auteurs principaux: García-Ortega, Lucía, Álvarez-García, Elisa, Gavilanes, José G., Martínez-del-Pozo, Álvaro, Joseph, Simpson
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2010
Sujets:
RNA
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896532/
https://ncbi.nlm.nih.gov/pubmed/20215430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq151
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