The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes

The ribotoxin α-sarcin belongs to a family of ribonucleases that cleave the sarcin/ricin loop (SRL), a critical functional rRNA element within the large ribosomal subunit (60S), thereby abolishing translation. Whether α-sarcin targets the SRL only in mature 60S subunits remains unresolved. Here, we...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Olombrada, Miriam, Peña, Cohue, Rodríguez-Galán, Olga, Klingauf-Nerurkar, Purnima, Portugal-Calisto, Daniela, Oborská-Oplová, Michaela, Altvater, Martin, Gavilanes, José G, Martínez-del-Pozo, Álvaro, de la Cruz, Jesús, García-Ortega, Lucía, Panse, Vikram Govind
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293039/
https://ncbi.nlm.nih.gov/pubmed/32365182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa315
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