Efficient in vivo antitumor effect of an immunotoxin based on ribotoxin α-sarcin in nude mice bearing human colorectal cancer xenografts

Tagging of RNases, such as the ribotoxin α-sarcin, with the variable domains of antibodies directed to surface antigens that are selectively expressed on tumor cells endows cellular specificity to their cytotoxic action. A recombinant single-chain immunotoxin based on the ribotoxin α-sarcin (IMTXA33...

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Detalhes bibliográficos
Publicado no:Springerplus
Main Authors: Tomé-Amat, Jaime, Olombrada, Miriam, Ruiz-de-la-Herrán, Javier, Pérez-Gómez, Eduardo, Andradas, Clara, Sánchez, Cristina, Martínez, Leopoldo, Martínez-del-Pozo, Álvaro, Gavilanes, José G, Lacadena, Javier
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393403/
https://ncbi.nlm.nih.gov/pubmed/25883890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40064-015-0943-5
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