A novel Carcinoembryonic Antigen (CEA)-Targeted Trimeric Immunotoxin shows significantly enhanced Antitumor Activity in Human Colorectal Cancer Xenografts

Immunotoxins are chimeric molecules, which combine antibody specificity to recognize and bind with high-affinity tumor-associated antigens (TAA) with the potency of the enzymatic activity of a toxin, in order to induce the death of target cells. Current immunotoxins present some limitations for canc...

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Publicado en:Sci Rep
Main Authors: Lázaro-Gorines, R., Ruiz-de-la-Herrán, J., Navarro, R., Sanz, L., Álvarez-Vallina, L., Martínez-del-Pozo, A., Gavilanes, J. G., Lacadena, J.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690998/
https://ncbi.nlm.nih.gov/pubmed/31406218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48285-z
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