Role of type-1 interferons in anti-glioma immunosurveillance - Using mouse studies to guide examination of novel prognostic markers in humans

PURPOSE: We hypothesized that the type-1 interferons (IFNs) would play a pivotal role in anti-glioma immunosurveillance through promotion of type-1 adaptive immunity and suppression of immunoregulatory cells. EXPERIMENTAL DESIGN: We induced de novo gliomas in Ifnar1(−/−) (deficient for type-1 IFN re...

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Main Authors: Fujita, Mitsugu, Scheurer, Michael E., Decker, Stacy A., McDonald, Heather A., Kohanbash, Gary, Kastenhuber, Edward R., Kato, Hisashi, Bondy, Melissa L., Ohlfest, John R., Okada, Hideho
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896455/
https://ncbi.nlm.nih.gov/pubmed/20472682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0644
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