Systemic Inhibition of Transforming Growth Factor-β in Glioma-Bearing Mice Improves the Therapeutic Efficacy of Glioma-Associated Antigen Peptide Vaccines

PURPOSE: A variety of cancers, including malignant gliomas, overexpress transforming growth factor-β (TGF-β), which helps tumors evade effective immune surveillance through a variety of mechanisms, including inhibition of CD8(+) cytotoxic T lymphocytes (CTL) and enhancing the generation of regulator...

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Bibliografiske detaljer
Main Authors: Ueda, Ryo, Fujita, Mitsugu, Zhu, Xinmei, Sasaki, Kotaro, Kastenhuber, Edward R., Kohanbash, Gary, McDonald, Heather A., Harper, Jay, Lonning, Scott, Okada, Hideho
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783346/
https://ncbi.nlm.nih.gov/pubmed/19861464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1067
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