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Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1

The RNase III endonuclease Dicer plays a key role in generation of microRNAs (miRs). We hypothesized that Dicer regulates cancer cell susceptibility to immune surveillance through miR processing. Indeed, Dicer disruption up-regulated intercellular cell adhesion molecule (ICAM)-1 and enhanced the sus...

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Detalhes bibliográficos
Main Authors: Ueda, Ryo, Kohanbash, Gary, Sasaki, Kotaro, Fujita, Mitsugu, Zhu, Xinmei, Kastenhuber, Edward R., McDonald, Heather A., Potter, Douglas M., Hamilton, Ronald L., Lotze, Michael T., Khan, Saleem A., Sobol, Robert W., Okada, Hideho
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705554/
https://ncbi.nlm.nih.gov/pubmed/19520829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811817106
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