GM-CSF promotes the immunosuppressive activity of glioma-Infiltrating myeloid cells through interleukin-4 receptor-α

Malignant gliomas are lethal cancers in the brain and heavily infiltrated by myeloid cells. Interleukin-4 receptor-α (IL-4Rα) mediates the immunosuppressive functions of myeloid cells, and polymorphisms in the IL-4Rα gene are associated with altered glioma risk and prognosis. In this study, we sough...

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Main Authors: Kohanbash, Gary, McKaveney, Kayla, Sakaki, Masashi, Ueda, Ryo, Mintz, Arlan H., Amankulor, Nduka, Fujita, Mitsugu, Ohlfest, John R., Okada, Hideho
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829000/
https://ncbi.nlm.nih.gov/pubmed/24030977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4124
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