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A Comparison of the Binding Sites of Matrix Metalloproteinases and Tumor Necrosis Factor-α Converting Enzyme: Implications for Selectivity

MMPs and TACE (ADAM-17) assume independent, parallel or opposite pathological roles in cancer, arthritis, and several other diseases. For therapeutic purposes, selective inhibition of individual MMPs and TACE is required in most cases due to distinct roles in diseases and the need to preserve activi...

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Bibliografiske detaljer
Main Authors: Lukacova, Viera, Zhang, Yufen, Kroll, Daniel M., Raha, Soumyendu, Comez, Dogan, Balaz, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896057/
https://ncbi.nlm.nih.gov/pubmed/15801829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0491703
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