FAAH(−/−) Mice Display Differential Tolerance, Dependence, and Cannabinoid Receptor Adaptation After Δ(9)-Tetrahydrocannabinol and Anandamide Administration

Repeated administration of Δ(9)-tetrahydrocannabinol (THC), the primary psychoactive constituent of Cannabis sativa, induces profound tolerance that correlates with desensitization and downregulation of CB(1) cannabinoid receptors in the CNS. However, the consequences of repeated administration of t...

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Detalhes bibliográficos
Main Authors: Falenski, Katherine W, Thorpe, Andrew J, Schlosburg, Joel E, Cravatt, Benjamin F, Abdullah, Rehab A, Smith, Tricia H, Selley, Dana E, Lichtman, Aron H, Sim-Selley, Laura J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895947/
https://ncbi.nlm.nih.gov/pubmed/20357755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2010.44
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