FAAH(−/−) Mice Display Differential Tolerance, Dependence, and Cannabinoid Receptor Adaptation After Δ(9)-Tetrahydrocannabinol and Anandamide Administration

Repeated administration of Δ(9)-tetrahydrocannabinol (THC), the primary psychoactive constituent of Cannabis sativa, induces profound tolerance that correlates with desensitization and downregulation of CB(1) cannabinoid receptors in the CNS. However, the consequences of repeated administration of t...

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Autores principales: Falenski, Katherine W, Thorpe, Andrew J, Schlosburg, Joel E, Cravatt, Benjamin F, Abdullah, Rehab A, Smith, Tricia H, Selley, Dana E, Lichtman, Aron H, Sim-Selley, Laura J
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895947/
https://ncbi.nlm.nih.gov/pubmed/20357755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2010.44
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