Δ(9)-Tetrahydrocannabinol and Endocannabinoid Degradative Enzyme Inhibitors Attenuate Intracranial Self-Stimulation in Mice

A growing body of evidence implicates endogenous cannabinoids as modulators of the mesolimbic dopamine system and motivated behavior. Paradoxically, the reinforcing effects of Δ(9)-tetrahydrocannabinol (THC), the primary psychoactive constituent of cannabis, have been difficult to detect in preclini...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Wiebelhaus, Jason M., Grim, Travis W., Owens, Robert A., Lazenka, Matthew F., Sim-Selley, Laura J., Abdullah, Rehab A., Niphakis, Micah J., Vann, Robert E., Cravatt, Benjamin F., Wiley, Jenny L., Negus, S. Stevens, Lichtman, Aron H.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Behavioral Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293433/
https://ncbi.nlm.nih.gov/pubmed/25398241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.218677
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