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PIP(2)-Binding Site in Kir Channels: Definition by Multiscale Biomolecular Simulations

[Image: see text] Phosphatidylinositol bisphosphate (PIP(2)) is an activator of mammalian inwardly rectifying potassium (Kir) channels. Multiscale simulations, via a sequential combination of coarse-grained and atomistic molecular dynamics, enabled exploration of the interactions of PIP(2) molecules...

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Autori principali: Stansfeld, Phillip J., Hopkinson, Richard, Ashcroft, Frances M., Sansom, Mark S. P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2009
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895862/
https://ncbi.nlm.nih.gov/pubmed/19839652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9013193
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