ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

We report ALS-linked superoxide dismutase-1 (SOD1) mutants of different biochemical characteristics disrupt the blood-spinal cord barrier in mice by reducing the levels of the tight junction proteins ZO-1, occludin and claudin-5 between endothelial cells. This results in microhemorrhages with releas...

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Autors principals: Zhong, Zhihui, Deane, Rashid, Ali, Zarina, Parisi, Margaret, Shapovalov, Yuriy, O’Banion, Kerry, Stojanovic, Konstantin, Sagare, Abhay, Boillee, Severine, Cleveland, Don W., Zlokovic, Berislav V.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895310/
https://ncbi.nlm.nih.gov/pubmed/18344992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn2073
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