The use of native cation-exchange chromatography to study aggregation and phase separation of monoclonal antibodies

This study introduces a novel analytical approach for studying aggregation and phase separation of monoclonal antibodies (mAbs). The approach is based on using analytical scale cation-exchange chromatography (CEX) for measuring the loss of soluble monomer in the case of individual and mixed protein...

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Bibliografiske detaljer
Main Authors: Chen, Shuang, Lau, Hollis, Brodsky, Yan, Kleemann, Gerd R, Latypov, Ramil F
Format: Artigo
Sprog:Inglês
Udgivet: Wiley Subscription Services, Inc., A Wiley Company 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895243/
https://ncbi.nlm.nih.gov/pubmed/20512972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.396
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