Hyphenation of strong cation exchange chromatography to native mass spectrometry for high throughput online characterization of charge heterogeneity of therapeutic monoclonal antibodies

Characterization of charge heterogeneity in monoclonal antibodies (mAbs) is needed during developability assessment and downstream development of drug candidates. Charge heterogeneity can come from post-translational modifications like deamidation, isomerization, and sialylation. Elucidation of char...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Ma, Fengfei, Raoufi, Fahimeh, Bailly, Marc Andre, Fayadat-Dilman, Laurence, Tomazela, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299211/
https://ncbi.nlm.nih.gov/pubmed/32370592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1763762
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