Hyphenation of strong cation exchange chromatography to native mass spectrometry for high throughput online characterization of charge heterogeneity of therapeutic monoclonal antibodies

Characterization of charge heterogeneity in monoclonal antibodies (mAbs) is needed during developability assessment and downstream development of drug candidates. Charge heterogeneity can come from post-translational modifications like deamidation, isomerization, and sialylation. Elucidation of char...

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Vydáno v:MAbs
Hlavní autoři: Ma, Fengfei, Raoufi, Fahimeh, Bailly, Marc Andre, Fayadat-Dilman, Laurence, Tomazela, Daniela
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299211/
https://ncbi.nlm.nih.gov/pubmed/32370592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1763762
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