Hyphenation of strong cation exchange chromatography to native mass spectrometry for high throughput online characterization of charge heterogeneity of therapeutic monoclonal antibodies

Characterization of charge heterogeneity in monoclonal antibodies (mAbs) is needed during developability assessment and downstream development of drug candidates. Charge heterogeneity can come from post-translational modifications like deamidation, isomerization, and sialylation. Elucidation of char...

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Bibliografski detalji
Izdano u:MAbs
Glavni autori: Ma, Fengfei, Raoufi, Fahimeh, Bailly, Marc Andre, Fayadat-Dilman, Laurence, Tomazela, Daniela
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2020
Teme:
Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299211/
https://ncbi.nlm.nih.gov/pubmed/32370592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1763762
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