Hyphenation of strong cation exchange chromatography to native mass spectrometry for high throughput online characterization of charge heterogeneity of therapeutic monoclonal antibodies

Characterization of charge heterogeneity in monoclonal antibodies (mAbs) is needed during developability assessment and downstream development of drug candidates. Charge heterogeneity can come from post-translational modifications like deamidation, isomerization, and sialylation. Elucidation of char...

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Опубликовано в: :MAbs
Главные авторы: Ma, Fengfei, Raoufi, Fahimeh, Bailly, Marc Andre, Fayadat-Dilman, Laurence, Tomazela, Daniela
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2020
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Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299211/
https://ncbi.nlm.nih.gov/pubmed/32370592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1763762
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