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The use of native cation-exchange chromatography to study aggregation and phase separation of monoclonal antibodies
This study introduces a novel analytical approach for studying aggregation and phase separation of monoclonal antibodies (mAbs). The approach is based on using analytical scale cation-exchange chromatography (CEX) for measuring the loss of soluble monomer in the case of individual and mixed protein...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2895243/ https://ncbi.nlm.nih.gov/pubmed/20512972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.396 |
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