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Activity of any class IA PI3K isoform can sustain cell proliferation and survival
Small molecule inhibitors of PI3K for oncology mainly target the class I PI3Ks, comprising the p110α, β, γ, and δ isoforms, of which only p110α is mutated in cancer. To assess the roles of class I PI3K isoforms in cell proliferation and survival, we generated immortalized mouse leukocyte and fibrobl...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2895061/ https://ncbi.nlm.nih.gov/pubmed/20534549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906461107 |
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