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Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes

Enediynes are potent antitumor antibiotics that are classified as 9- or 10-membered according to the size of the enediyne core structure. However, almost nothing is known about enediyne core biosynthesis, and the determinants of 9- versus 10-membered enediyne core biosynthetic divergence remain elus...

詳細記述

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書誌詳細
主要な著者: Horsman, Geoff P., Chen, Yihua, Thorson, Jon S., Shen, Ben
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895059/
https://ncbi.nlm.nih.gov/pubmed/20534556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003442107
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