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Enhanced neuronal RNAi in C. elegans using SID-1

We expressed SID-1, a transmembrane protein from Caenorhabditis elegans that is required for systemic RNAi, in C. elegans neurons. This expression increased the response of neurons to dsRNA delivered by feeding. Mutations in the lin-15b and lin-35 genes further enhanced this effect. Worms expressing...

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Detalhes bibliográficos
Main Authors: Calixto, Andrea, Chelur, Dattananda, Topalidou, Irini, Chen, Xiaoyin, Chalfie, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894993/
https://ncbi.nlm.nih.gov/pubmed/20512143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1463
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