Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A

The botulinum neurotoxin serotype A light chain (BoNT/A LC) protease is the catalytic component responsible for the neuroparalysis that is characteristic of the disease state botulism. Three related peptide-like molecules (PLMs) were designed using previous information from co-crystal structures, sy...

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Main Authors: Zuniga, Jorge E., Hammill, Jared T., Drory, Omri, Nuss, Jonathan E., Burnett, James C., Gussio, Rick, Wipf, Peter, Bavari, Sina, Brunger, Axel T.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894858/
https://ncbi.nlm.nih.gov/pubmed/20614028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011378
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