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Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of PD-1

CD4(+)FoxP3(+) regulatory T cells (T(reg)) play a critical role in maintaining self tolerance and inhibiting autoimmune disease. Despite being a major focus of modern immunological investigation, many aspects of T(reg) biology remain unknown. In a screen for novel candidate genes involved in human T...

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Autors principals: Swainson, Louise A., Mold, Jeff E., Bajpai, Urmila D., McCune, Joseph M.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894810/
https://ncbi.nlm.nih.gov/pubmed/20190142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903943
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