A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism

BACKGROUND: Opioids are the most widely used analgesics for the treatment of clinical pain. They produce their therapeutic effects by binding to μ-opioid receptors (MORs), which are 7 transmembrane domain (7TM) G-protein-coupled receptors (GPCRs), and inhibiting cellular activity. However, the analg...

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Bibliografske podrobnosti
Main Authors: Gris, Pavel, Gauthier, Josee, Cheng, Philip, Gibson, Dustin G, Gris, Denis, Laur, Oskar, Pierson, John, Wentworth, Sean, Nackley, Andrea G, Maixner, William, Diatchenko, Luda
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894766/
https://ncbi.nlm.nih.gov/pubmed/20525224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-6-33
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