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Prediction of protease substrates using sequence and structure features

Motivation:Granzyme B (GrB) and caspases cleave specific protein substrates to induce apoptosis in virally infected and neoplastic cells. While substrates for both types of proteases have been determined experimentally, there are many more yet to be discovered in humans and other metazoans. Here, we...

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Detalhes bibliográficos
Main Authors: Barkan, David T., Hostetter, Daniel R., Mahrus, Sami, Pieper, Ursula, Wells, James A., Craik, Charles S., Sali, Andrej
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894511/
https://ncbi.nlm.nih.gov/pubmed/20505003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btq267
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