Procleave: Predicting Protease-specific Substrate Cleavage Sites by Combining Sequence and Structural Information

Proteases are enzymes that cleave and hydrolyse the peptide bonds between two specific amino acid residues of target substrate proteins. Protease-controlled proteolysis plays a key role in the degradation and recycling of proteins, which is essential for various physiological processes. Thus, solvin...

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Bibliographic Details
Main Authors: Fuyi Li, Andre Leier, Quanzhong Liu, Yanan Wang, Dongxu Xiang, Tatsuya Akutsu, Geoffrey I. Webb, A. Ian Smith, Tatiana Marquez-Lago, Jian Li, Jiangning Song
Format: Artigo
Language:Inglês
Published: Elsevier 2020-02-01
Series:Genomics, Proteomics & Bioinformatics
Subjects:
Protease
Cleavage site prediction
Machine learning
Conditional random field
Structural determinants
Online Access:http://www.sciencedirect.com/science/article/pii/S167202292030053X
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