DNA polymerases ν and θ are required for efficient immunoglobulin V gene diversification in chicken

The chicken DT40 B lymphocyte line diversifies its immunoglobulin (Ig) V genes through translesion DNA synthesis–dependent point mutations (Ig hypermutation) and homologous recombination (HR)–dependent Ig gene conversion. The error-prone biochemical characteristic of the A family DNA polymerases Pol...

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Detalhes bibliográficos
Main Authors: Kohzaki, Masaoki, Nishihara, Kana, Hirota, Kouji, Sonoda, Eiichiro, Yoshimura, Michio, Ekino, Shigeo, Butler, John E., Watanabe, Masami, Halazonetis, Thanos D., Takeda, Shunichi
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894443/
https://ncbi.nlm.nih.gov/pubmed/20584917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200912012
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