Genetic Evidence for Single-Strand Lesions Initiating Nbs1-Dependent Homologous Recombination in Diversification of Ig V in Chicken B Lymphocytes

Homologous recombination (HR) is initiated by DNA double-strand breaks (DSB). However, it remains unclear whether single-strand lesions also initiate HR in genomic DNA. Chicken B lymphocytes diversify their Immunoglobulin (Ig) V genes through HR (Ig gene conversion) and non-templated hypermutation....

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Detalhes bibliográficos
Main Authors: Nakahara, Makoto, Sonoda, Eiichiro, Nojima, Kuniharu, Sale, Julian E., Takenaka, Katsuya, Kikuchi, Koji, Taniguchi, Yoshihito, Nakamura, Kyoko, Sumitomo, Yoshiki, Bree, Ronan T., Lowndes, Noel F., Takeda, Shunichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2625440/
https://ncbi.nlm.nih.gov/pubmed/19180185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000356
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