Methylation Analysis of MLH1 Improves the Selection of Patients for Genetic Testing in Lynch Syndrome

Inactivation of MLH1 due to promoter hypermethylation strongly suggests a sporadic origin, providing exclusion criteria for Lynch syndrome. The aim of this study is to compare the utility of methylation analysis of MLH1 and BRAF V600E mutations for the selection of patients with MLH1 negative colore...

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Hlavní autoři: Pérez-Carbonell, Lucía, Alenda, Cristina, Payá, Artemio, Castillejo, Adela, Barberá, Víctor M., Guillén, Carmen, Rojas, Estefanía, Acame, Nuria, Gutiérrez-Aviñó, Francisco J., Castells, Antoni, Llor, Xavier, Andreu, Montserrat, Soto, José-Luis, Jover, Rodrigo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2010
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893635/
https://ncbi.nlm.nih.gov/pubmed/20489114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2010.090212
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