UTILITY OF P16 IMMUNOHISTOCHEMISTRY FOR THE IDENTIFICATION OF LYNCH SYNDROME

Immunohistochemistry for mismatch repair proteins has shown utility in the identification of Lynch syndrome, but majority of tumours with loss MLH1 expression are due to sporadic hypermethylation of the MLH1 promoter. These tumours can also show epigenetic silencing of other genes, such as p16. The...

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Detalhes bibliográficos
Main Authors: Payá, Artemio, Alenda, Cristina, Pérez-Carbonell, Lucía, Rojas, Estefanía, Soto, José-Luis, Guillén, Carmen, Castillejo, Adela, Barberá, Victor M., Carrato, Alfredo, Castells, Antoni, Llor, Xavier, Andreu, Montserrat, Koh, Jim, Enders, Greg H., Benlloch, Susana, Jover, Rodrigo
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825754/
https://ncbi.nlm.nih.gov/pubmed/19383812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-3116
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