Comparison of Sanger Sequencing, Pyrosequencing, and Melting Curve Analysis for the Detection of KRAS Mutations: Diagnostic and Clinical Implications

Mutations in codons 12 and 13 of the KRAS oncogene are relatively common in colorectal and lung adenocarcinomas. Recent data indicate that these mutations result in resistance to anti-epidermal growth factor receptor therapy. Therefore, we assessed Sanger sequencing, pyrosequencing, and melting curv...

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Main Authors: Tsiatis, Athanasios C., Norris-Kirby, Alexis, Rich, Roy G., Hafez, Michael J., Gocke, Christopher D., Eshleman, James R., Murphy, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2010
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Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893626/
https://ncbi.nlm.nih.gov/pubmed/20431034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2010.090188
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