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COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma

BACKGROUND: KRAS mutational analysis is the standard of care prior to initiation of treatments targeting the epidermal growth factor receptor (EGFR) in patients with metastatic colorectal cancer. Sensitive methods are required to reliably detect KRAS mutations in tumor samples due to admixture with...

詳細記述

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書誌詳細
主要な著者: Pritchard, Colin C, Akagi, Laura, Reddy, Poluru L, Joseph, Loren, Tait, Jonathan F
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001699/
https://ncbi.nlm.nih.gov/pubmed/21110880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6890-10-6
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