COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma

BACKGROUND: KRAS mutational analysis is the standard of care prior to initiation of treatments targeting the epidermal growth factor receptor (EGFR) in patients with metastatic colorectal cancer. Sensitive methods are required to reliably detect KRAS mutations in tumor samples due to admixture with...

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Hlavní autoři: Pritchard, Colin C, Akagi, Laura, Reddy, Poluru L, Joseph, Loren, Tait, Jonathan F
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Technical Advance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001699/
https://ncbi.nlm.nih.gov/pubmed/21110880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6890-10-6
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