COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma

BACKGROUND: KRAS mutational analysis is the standard of care prior to initiation of treatments targeting the epidermal growth factor receptor (EGFR) in patients with metastatic colorectal cancer. Sensitive methods are required to reliably detect KRAS mutations in tumor samples due to admixture with...

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Main Authors: Pritchard, Colin C, Akagi, Laura, Reddy, Poluru L, Joseph, Loren, Tait, Jonathan F
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
Assuntos:
Technical Advance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001699/
https://ncbi.nlm.nih.gov/pubmed/21110880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6890-10-6
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