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COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma

BACKGROUND: KRAS mutational analysis is the standard of care prior to initiation of treatments targeting the epidermal growth factor receptor (EGFR) in patients with metastatic colorectal cancer. Sensitive methods are required to reliably detect KRAS mutations in tumor samples due to admixture with...

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Autori principali: Pritchard, Colin C, Akagi, Laura, Reddy, Poluru L, Joseph, Loren, Tait, Jonathan F
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001699/
https://ncbi.nlm.nih.gov/pubmed/21110880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6890-10-6
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