The Use of COLD-PCR and High-Resolution Melting Analysis Improves the Limit of Detection of KRAS and BRAF Mutations in Colorectal Cancer

Fast and reliable tests to detect mutations in human cancers are required to better define clinical samples and orient targeted therapies. KRAS mutations occur in 30–50% of colorectal cancers (CRCs) and represent a marker of clinical resistance to cetuximab therapy. In addition, the BRAF V600E is mu...

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Main Authors: Mancini, Irene, Santucci, Claudio, Sestini, Roberta, Simi, Lisa, Pratesi, Nicola, Cianchi, Fabio, Valanzano, Rosa, Pinzani, Pamela, Orlando, Claudio
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Investigative Pathology 2010
Ábhair:
Regular Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928436/
https://ncbi.nlm.nih.gov/pubmed/20616366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2010.100018
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