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Generating a Prion with Bacterially Expressed Recombinant Prion Protein
The prion hypothesis posits that a misfolded form of prion protein (PrP) is responsible for the infectivity of prion disease. Using recombinant murine PrP purified from Escherichia coli, we created a recombinant prion with the hallmarks of the pathogenic PrP isoform: aggregated, protease-resistant,...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2893558/ https://ncbi.nlm.nih.gov/pubmed/20110469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1183748 |
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