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Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene

Mutations in LMNA, which encodes A-type nuclear lamins, cause disorders of striated muscle that have as a common feature dilated cardiomyopathy. We have demonstrated an abnormal activation of both the extracellular signal-regulated kinase (ERK) and the c-Jun N-terminal kinase (JNK) branches of the m...

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Autori principali: Wu, Wei, Shan, Jian, Bonne, Gisèle, Worman, Howard J., Muchir, Antoine
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893287/
https://ncbi.nlm.nih.gov/pubmed/20388542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2010.04.001
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