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Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins

Autosomal Emery–Dreifuss muscular dystrophy and related disorders with dilated cardiomyopathy and variable skeletal muscle involvement are caused by mutations in LMNA, which encodes A-type nuclear lamins. How alterations in A-type lamins, intermediate filament proteins of the nuclear envelope expres...

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Detalhes bibliográficos
Main Authors: Muchir, Antoine, Shan, Jian, Bonne, Gisèle, Lehnart, Stephan E., Worman, Howard J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638780/
https://ncbi.nlm.nih.gov/pubmed/18927124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn343
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