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Mechanisms of p53-mediated Repression of the Human Polycystic Kidney Disease-1 Promoter
We previously reported that the tumor suppressor protein p53 participates in a negative feedback loop to fine-tune PKD1 gene expression. This physiological pathway is believed to prevent polycystin-1 overexpression and thus renal cysts. The present study examined the mechanisms of p53-mediated repre...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2893251/ https://ncbi.nlm.nih.gov/pubmed/20388565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2010.04.001 |
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