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Mutation of Cysteine Residue 455 to Alanine in Human Topoisomerase IIα Confers Hypersensitivity to Quinones: Enhancing DNA Scission by Closing the N-terminal Protein Gate
Several quinone-based metabolites of industrial and environmental toxins are potent topoisomerase II poisons. These compounds act by adducting the protein, and previous studies suggest that they increase levels of enzyme-associated DNA strand breaks by at least two potential mechanisms. Quinones act...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2893044/ https://ncbi.nlm.nih.gov/pubmed/17516663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx700062t |
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