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Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations

Hepatitis B virus (HBV) clone 4B replicated much more efficiently than clone 2A of the same genotype. Introduction of its T1753C, A1762T, G1764A, and C1766T core promoter mutations into the 2A genome greatly enhanced genome replication and suppressed HBeAg expression. Here we show that these effects...

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Bibliografiske detaljer
Main Authors: Tsai, Adrienne, Kawai, Shigenobu, Kwei, Karen, Gewaily, Dina, Hutter, Alexander, Tong, David R., Li, Jisu, Wands, Jack R., Tong, Shuping
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893023/
https://ncbi.nlm.nih.gov/pubmed/19327810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.03.002
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