Lack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genes

Colorectal cancers (CRC) develop on the basis of a deficient DNA mismatch repair (MMR) system in about 15% of cases. MMR-deficient CRC lesions show high level microsatellite instability (MSI-H) and accumulate numerous mutations located at coding microsatellite loci that lead to the generation of imm...

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Main Authors:	Michel, Sara, Linnebacher, Michael, Alcaniz, Joshua, Voss, Maike, Wagner, Rudolf, Dippold, Wolfgang, Becker, Christina, von Knebel Doeberitz, Magnus, Ferrone, Soldano, Kloor, Matthias
Format:	Artigo
Sprog:	Inglês
Udgivet:	2010
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2892639/ https://ncbi.nlm.nih.gov/pubmed/20013806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25106
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Lack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genes

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