Darinaparsin Induces a Unique Cellular Response and is Active in an Arsenic Trioxide-Resistant Myeloma Cell Line

Here we report on organic arsenical darinaparsin (DAR, ZIO-101, S-dimethylarsino-glutathione) and its anti-myeloma activity compared with inorganic arsenic trioxide (ATO). Darinaparsin induced apoptosis in multiple myeloma cell lines in a dose-dependent manner, and the addition of N-acetylcysteine,...

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Bibliografiske detaljer
Main Authors: Matulis, Shannon M., Morales, Alejo A., Yehiayan, Lucy, Croutch, Claire, Gutman, Delia, Cai, Yong, Lee, Kelvin P., Boise, Lawrence H.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891844/
https://ncbi.nlm.nih.gov/pubmed/19417148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-1072
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