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The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients

Mutations in Notch3 cause CADASIL (cerebral autosomal dominant adult onset arteriopathy), which leads to stroke and dementia in humans. CADASIL arteriopathy is characterized by major alterations of vascular smooth muscle cells and the presence of specific granular osmiophilic deposits. Patients carr...

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書誌詳細
主要な著者: Joutel, Anne, Andreux, Fréderic, Gaulis, Swann, Domenga, Valérie, Cecillon, Michaelle, Battail, Nicole, Piga, Nadia, Chapon, Françoise, Godfrain, Catherine, Tournier-Lasserve, Elisabeth
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2000
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC289174/
https://ncbi.nlm.nih.gov/pubmed/10712431
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