The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients

Mutations in Notch3 cause CADASIL (cerebral autosomal dominant adult onset arteriopathy), which leads to stroke and dementia in humans. CADASIL arteriopathy is characterized by major alterations of vascular smooth muscle cells and the presence of specific granular osmiophilic deposits. Patients carr...

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Main Authors: Joutel, Anne, Andreux, Fréderic, Gaulis, Swann, Domenga, Valérie, Cecillon, Michaelle, Battail, Nicole, Piga, Nadia, Chapon, Françoise, Godfrain, Catherine, Tournier-Lasserve, Elisabeth
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2000
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC289174/
https://ncbi.nlm.nih.gov/pubmed/10712431
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