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Pathogenic Mutations Associated with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Differently Affect Jagged1 Binding and Notch3 Activity via the RBP/JK Signaling Pathway

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited vascular dementia characterized by the degeneration of smooth-muscle cells in small cerebral arteries. CADASIL is caused by mutations in NOTCH3, one of the four mammalian homologs to...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Joutel, Anne, Monet, Marie, Domenga, Valérie, Riant, Florence, Tournier-Lasserve, Elisabeth
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society of Human Genetics 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1181931/
https://ncbi.nlm.nih.gov/pubmed/14714274
Tagiau: Ychwanegu Tag
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