Transgenic Mice Expressing Mutant Notch3 Develop Vascular Alterations Characteristic of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an increasingly recognized adult-onset autosomal dominant vascular dementia, caused by highly stereotyped mutations in the Notch3 receptor. CADASIL is a widespread angiopathy characterized by a de...

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Main Authors: Ruchoux, Marie Magdeleine, Domenga, Valérie, Brulin, Peggy, Maciazek, Jacqueline, Limol, Sylvie, Tournier-Lasserve, Elisabeth, Joutel, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2003
Assuntos:
Animal Model
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851116/
https://ncbi.nlm.nih.gov/pubmed/12507916
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