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Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy

BACKGROUND AND PURPOSE: CADASIL is an inherited small-vessel disease responsible for lacunar strokes and cognitive impairment. The disease is caused by highly stereotyped mutations in Notch3, expression of which is highly restricted to vascular smooth muscle cells (vSMC). The underlying vasculopathy...

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Hlavní autoři: Dubroca, Caroline, Lacombe, Pierre, Domenga, Valérie, Maciazek, Jacqueline, Levy, Bernard, Tournier-Lasserve, Elisabeth, Joutel, Anne, Henrion, Daniel
Médium: Artigo
Jazyk:Inglês
Vydáno: Lippincott Williams & Wilkins 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234452/
https://ncbi.nlm.nih.gov/pubmed/15569862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/01.STR.0000149949.92854.45
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