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MMP-2 Alters VEGF Expression via αVβ3 Integrin-Mediated PI3K/AKT Signaling in A549 Lung Cancer Cells

Vascular endothelial growth factor (VEGF) is one of the most important angiogenic growth factors for tumor angiogenesis. Here, we sought to explore whether RNA interference (RNAi) targeting Matrix metalloproteinase-2 (MMP-2) could disrupt VEGF mediated angiogenesis in lung cancer. MMP-2 siRNA inhibi...

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Bibliografiske detaljer
Main Authors: Chetty, Chandramu, Lakka, Sajani S., Bhoopathi, Praveen, Rao, Jasti S.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891576/
https://ncbi.nlm.nih.gov/pubmed/20027628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25134
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