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Blockade of tumor growth due to MMP-9 inhibition is mediated by sequential activation of β1 integrin, ERK and NFκB
We previously showed that MMP-9 inhibition using an adenoviral-mediated delivery of MMP-9 siRNA (Ad-MMP-9), caused senescence in medulloblastoma cells. Regardless of whether or not, Ad-MMP-9 would induce apoptosis, the possible signaling mechanism is still obscure. In this report, we demonstrate tha...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2206181/ https://ncbi.nlm.nih.gov/pubmed/17991734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707931200 |
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