Blockade of tumor growth due to MMP-9 inhibition is mediated by sequential activation of β1 integrin, ERK and NFκB

We previously showed that MMP-9 inhibition using an adenoviral-mediated delivery of MMP-9 siRNA (Ad-MMP-9), caused senescence in medulloblastoma cells. Regardless of whether or not, Ad-MMP-9 would induce apoptosis, the possible signaling mechanism is still obscure. In this report, we demonstrate tha...

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Detalhes bibliográficos
Main Authors: Bhoopathi, Praveen, Chetty, Chandramu, Kunigal, Sateesh, Vanamala, Sravan K., Rao, Jasti S., Lakka, Sajani S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206181/
https://ncbi.nlm.nih.gov/pubmed/17991734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707931200
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