Suppression of MMP-2 Attenuates TNF-α Induced NF-κB Activation and Leads to JNK Mediated Cell Death in Glioma

BACKGROUND: Abrogation of apoptosis for prolonged cell survival is essential in cancer progression. In our previous studies, we showed the MMP-2 downregulation induced apoptosis in cancer cell lines. Here, we attempt to investigate the exact molecular mechanism of how MMP-2 depletion leads to apopto...

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Detalhes bibliográficos
Main Authors: Kesanakurti, Divya, Chetty, Chandramu, Bhoopathi, Praveen, Lakka, Sajani S., Gorantla, Bharathi, Tsung, Andrew J., Rao, Jasti S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087754/
https://ncbi.nlm.nih.gov/pubmed/21573233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019341
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